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Farxiga

What is Farxiga? Uses and Side Effects

Farxiga | What is Farxiga

Farxiga is a brand-name prescription medication that contains the drug dapagliflozin. Farxiga is used to improve blood sugar levels in adults with type 2 diabetes. It comes as a tablet you take by mouth.

Farxiga belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. In clinical studies, Farxiga decreased fasting blood sugar levels by 28.8 mg/dL and hemoglobin A1c (HbA1c) by 0.9 percent after 24 weeks of treatment. About 44 to 51 percent of people in the studies who took Farxiga for 24 weeks reached their goal HbA1c of less than 7 percent.

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Farxiga can be used by itself or along with other diabetes medications.

Farxiga Generic

Farxiga is only available as a brand-name drug. It contains the drug dapagliflozin, which isn’t currently available in generic form.

Farxiga Side Effects

Farxiga can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking Farxiga. This list doesn’t include all possible side effects.

For more information on the possible side effects of Farxiga, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

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Call your doctor at once if you have:

  • little or no urination;
  • dehydration symptoms – dizziness, weakness, feeling light-headed (like you might pass out);
  • ketoacidosis (too much acid in the blood) – nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or
  • signs of a bladder infection – pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back.

Some people taking this medicine have had bladder cancer, but it is not clear if dapagliflozin was the actual cause.

Side effects may be more likely to occur in older adults.

Common Farxiga side effects may include:

  • genital yeast infection;
  • urinating more than usual; or
  • sore throat and runny or stuffy nose.

Weight loss

A beneficial side effect of Farxiga is weight loss. In clinical studies, people taking Farxiga lost up to about 7 pounds over 24 weeks of treatment.

Farxiga should only be used according to your doctor’s prescription. You shouldn’t use Farxiga without your doctor’s guidance.

Back pain

In clinical studies, back pain occurred in up to 4 percent of people taking Farxiga. This side effect may go away with continued used of the drug. If you have back pain that doesn’t go away or becomes severe, talk with your doctor.

Yeast infection

Farxiga can increase your risk of genital yeast infection. In clinical studies, yeast infection occurred in up to about 8 percent of women and about 3 percent in men taking Farxiga.

If you’ve never had a yeast infection before and think you might have one, see your doctor for a diagnosis and treatment.

Farxiga Precautions

Before taking dapagliflozin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease/failure (dialysis), bladder cancer, loss of too much body water (dehydration), use/abuse of alcohol, low blood pressure, heart failure, history of yeast infections in the vagina or penis.

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar and a high ketone level.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Also, if you are eating less or not able to eat due to these conditions or any illness, this can lead to a high ketone level while you are taking this medication. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar or ketone testing.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness/fainting (usually when standing), dehydration, and kidney disease.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).

Farxiga Cost

This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for Farxiga oral tablet 5 mg is around $523 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Farxiga is available as a brand name drug only, a generic version is not yet available. For more information, read about generic availability.

Farxiga Dosage

Farxiga Tablet

  • 5mg
  • 10mg

Type 2 Diabetes Mellitus

Indicated as an adjunct to diet and exercise to improve glycemic control with type 2 diabetes mellitus

Initial: 5 mg PO qDay

May increase to 10 mg qDay in patients tolerating 5 mg/day who require additional glycemic control

Dosage Modifications

Renal impairment

  • eGFR ≥45mL/min/1.73 m²: No dosage adjustment required
  • eGFR 30-45 mL/min/1.73 m²: Not recommended
  • eGFR <30 mL/min/1.73 m²: Contraindicated

Hepatic impairment

  • Mild or moderate: No dosage adjustment required
  • Severe: Not studied

Dosing Considerations

Limitation of use: Not for treatment of type 1 diabetes mellitus or diabetic ketoacidosis

Before initiation

  • Assess renal function and periodically thereafter
  • In patients with volume depletion, correct this condition

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